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KMID : 0438219780150030295
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Korea University Medical Journal
1978 Volume.15 No. 3 p.295 ~ p.303
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Influences of LiCl and alcohol on convulsive effect of picrotoxin
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Abstract
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Schou reported that the inhibitory effect of lithium on the ion transport in brain slices was similar to that of ethanol, and recently the clinical efficiency of lithium on alcohol withdrawal and chronic alcoholices has been reported. But little is known about the anticonvulsant effect of lithium and the interaction between lithium and alcohol in their anticonvulsant effect.
In this paper, the influences of lithium and ethanol on the convulsion induced by picrotoxin and the changes of serum electrolyte (: Na, K, Ca and Mg) levels during and after the convulsion were studied, respectively. The anticonvulsant action was determined by the prolongation of the onset time of convulsion after picrotoxin subcutaneous injection to mice.
The results obtained were summarized as follows:
1. The onset time of convulsion by picrotoxin was markedly prolongated by the pretreatment of lithium, ethanol, or lithium and ethanol, respectively.
2. The serum electrolyte (:Na, K, Ca and Mg) levels were not changed during and after the convulsion induced by picrotoxin.
3. The serum K and Mg levels were increased by lithium, but the serum Ca level was decreased by it. And then,. comparing with the changes of serum electrolyte levels by lithium, the serum Mg level was more markedly increased by the picrotoxin injection after the lithium pretreatment. but the other electrolyte levels were not changed by that.
4. The serum K level was decreased by ethanol, but the other electrolyte levels were not changed
by it. And then, comparing with the changes of serum electrolyte levels by ethanol, the serum
K level was more markedly decreased by picrotoxin injection after the ethanol pretreatment.
5. The serum Na level was markedly decreased by picrotoxin injection after the the combined
pretreatment of lithium and ethanol, but the other electrolyte levels were not changed by that.
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